In the last few weeks I’ve tried to establish a workflow for anime style background starting from blender + freestyle ( used 2.79 , don’t know freestyle status on 2.8 ).
Reference image is jiyu gakuen girls school.
In blender I’ve created the buildings ( except for the one on the backgorund on the right, he’s from blend swap by bright on piers https://www.blendswap.com/blends/view/15424 ) and tried to get composition right.
In PS I've done all the overpainting
In substance designer I've created a few of noises and the window pattern.